Published March 2000
| Version v1
Journal article
Enzymatic synthesis of [3-14C] cinnamic acid
Creators
- 1. Warsaw Univ. (Poland). Dept. of Chemistry
Description
Convenient and efficient route of the synthesis of [3-14C] cinnamic acid is reported. [1-14C] Benzoic acid, prepared by carbonation of Grignard reagent with [14C] carbon dioxide, was reduced to [1-14C] benzyl alcohol. In the enzymatic step this alcohol was selectively oxidised to [1-14C] benzaldehyde using enzyme YADH (Ec. 1.1.1.1) and immediately condensed with malonic acid. This combined chemical and enzymatic approach allows to obtain [3-14C] cinnamic acid with radiochemical yield higher than 50% in respect to the starting alcohol. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Radioanalytical and Nuclear Chemistry
- Journal Volume
- 243
- Journal Issue
- 3
- Journal Page Range
- p. 635-638
- ISSN
- 0236-5731
- CODEN
- JRNCDM
INIS
- Country of Publication
- Hungary
- Country of Input or Organization
- Hungary
- INIS RN
- 31016951
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ALCOHOL DEHYDROGENASE; BENZYL ALCOHOL; CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; CINNAMIC ACID; LABELLED COMPOUNDS; OXIDATION
- Descriptors DEC
- ALCOHOLS; AROMATICS; CARBON COMPOUNDS; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; HEMIACETAL DEHYDROGENASES; HYDROXY COMPOUNDS; LABELLED COMPOUNDS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; SYNTHESIS
Optional Information
- Notes
- 15 refs.