The application of micronuclei determination in estimation of radiation dose

The frequencies of micronuclei, micro-nucleate cell and various micro-nucleate cell in human lymphocytes, which had been irradiated with 60Co gamma ray at different doses and dose rates, were investigated after 72 hours of irradiation. The results are as following: (1) the relationship between dose and frequency of micronuclei of frequency of micro-nucleate cell is a quadratic polynomial, and at high dose the exponential correction is needed. (2) The uncertainty of estimated dose by dose-effect curve is depending on the dose rate, especially, in the low dose range the influence is remarkable. (3) By using of different thresholds of dose and dose rate for appearing micro-nucleate cell, the dose and dose rate received by human body can be roughly estimated and the uncertainty can be reduced