Published April 2007
| Version v1
Journal article
Effects of external magnetic field on biodistribution of nanoparticles: A histological study
Creators
- 1. Department of Neurology, Chang Gung University College of Medicine and Memorial Hospital, 199 Tung-Hwa N Rd, Taipei, Taiwan (China)
- 2. Department of Chemical and Material Engineering, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan (China)
- 3. Department of Neurosurgery, Chang Gung University College of Medicine and Memorial Hospital, 199 Tung-Hwa N Rd, Taipei, Taiwan (China)
- 4. Department of Pathology, Chang Gung University College of Medicine and Memorial Hospital, 199 Tung-Hwa N Rd, Taipei, Taiwan (China)
- 5. Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan (China)
Description
This study investigates the effect of external magnetic fields on the biodistribution of nanoparticles (NP). A NdFeB magnet of 2.4 kG was externally applied over the left femoral artery or right kidney. The 250 nm dextran-coated Fe3O4 NP was injected via tail vein in healthy rats, and organs were taken 1 or 24 h later. Prussian blue stain revealed that NP were more rapidly retained in the liver and spleen than in the lungs. NP aggregation observed in the kidney and femoral artery after application of external magnets was time dependent. Hollow organs such as the intestine, colon, and urinary bladder retained little NP
Additional details
Identifiers
- DOI
- 10.1016/j.jmmm.2006.10.1202;
- PII
- S0304-8853(06)02602-3;
Publishing Information
- Journal Title
- Journal of Magnetism and Magnetic Materials
- Journal Volume
- 311
- Journal Issue
- 1
- Journal Page Range
- p. 372-375
- ISSN
- 0304-8853
- CODEN
- JMMMDC
Conference
- Title
- 6. international conference on the scientific and clinical applications of magnetic carriers
- Acronym
- SCAMC-06
- Dates
- 17-20 May 2006
- Place
- Krems (Austria)
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 39029997
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ARTERIES; BLADDER; CARRIERS; DEXTRAN; DISTRIBUTION; HISTOLOGY; IRON OXIDES; KIDNEYS; LARGE INTESTINE; LIVER; LUNGS; MAGNETIC FIELDS; MAGNETIC MATERIALS; MAGNETS; NANOSTRUCTURES; PARTICLES; RATS; SPLEEN; VEINS
- Descriptors DEC
- ANIMALS; BLOOD SUBSTITUTES; BLOOD VESSELS; BODY; CARBOHYDRATES; CARDIOVASCULAR SYSTEM; CHALCOGENIDES; DIGESTIVE SYSTEM; DRUGS; EQUIPMENT; GASTROINTESTINAL TRACT; GLANDS; HEMATOLOGIC AGENTS; INTESTINES; IRON COMPOUNDS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; POLYSACCHARIDES; RESPIRATORY SYSTEM; RODENTS; SACCHARIDES; TRANSITION ELEMENT COMPOUNDS; URINARY TRACT; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.