Published July 26, 2013 | Version v1
Journal article Metadata-only

First results on cell irradiation with laser-driven protons on the TARANIS system

Creators

  • 1. School of Mathematics and Physics, Queen's University Belfast, Belfast BT7 1NN (United Kingdom)
  • 2. School of Mathematics and Physics, Queen's University Belfast, Belfast BT7 1NN, UK and Institute of Physics of the ASCR, ELI-Beamlines Project, Prague (Czech Republic)
  • 3. CCRCB, Queen's University Belfast, Belfast BT7 1NN (United Kingdom)
  • 4. Dept. of Medical Physics, University Hospital, Birmingham, B15 2TH (United Kingdom)
  • 5. Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom)

Description

The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source

Additional details

Identifiers

DOI
10.1063/1.4816612;

Publishing Information

Journal Title
AIP Conference Proceedings
Journal Volume
1546
Journal Issue
1
Journal Page Range
p. 87-89
ISSN
0094-243X
CODEN
APCPCS

Conference

Title
2. ELIMED workshop and panel
Dates
18-19 Oct 2012
Place
Catania (Italy)

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
45039249
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; COMPARATIVE EVALUATIONS; DOSE RATES; EQUIVALENT RADIATION DOSES; IRRADIATION; MEV RANGE; PROTON BEAMS; PROTONS; RADIOTHERAPY; RBE; X-RAY SOURCES
Descriptors DEC
BARYONS; BEAMS; BIOLOGICAL EFFECTS; DOSES; ELEMENTARY PARTICLES; ENERGY RANGE; EVALUATION; FERMIONS; HADRONS; MEDICINE; NUCLEAR MEDICINE; NUCLEON BEAMS; NUCLEONS; PARTICLE BEAMS; RADIATION DOSES; RADIATION EFFECTS; RADIATION SOURCES; RADIOLOGY; THERAPY

Optional Information

Notes
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