Relationship between coronary artery stenosis and renal dysfunction. Comparisons of multidetector-row CT coronary angiograms with estimated glomerular filtration rates

The relationship between chronic kidney disease (CKD) and cardiovascular diseases has recently received considerable focus. We compared estimated glomerular filtration rates (eGFR) with coronary stenosis visually assessed by CT coronary angiography (CTCA) in 578 patients (285 men, 293 women; average age, 68 y). Among these, 520 assessable patients were classified according to stenosis rates of <25%, 25-49%, 50-74% and ≥75% as normal coronary arteries (n=232), slight (n=102), moderate (n=70) and severe (n=116) stenosis, respectively. They were also classified by eGFR (ml/min/1.73 m2) values of ≥90, 60-90 and <60 as having normal (n=119) or slight (n=314) renal dysfunction and CKD (n=87), respectively. The average (±standard deviation; SD) eGFR values of the groups with normal arteries, slight, moderate and severe stenosis were 83.39±20.49, 78.54±18.37, 74.05±18.75 and 68.78±17.53, respectively. The ratios of patients with >50% stenosis and who had previously undergone percutaneous coronary intervention (PCI) among the groups with normal and slight renal dysfunction and CKD were 23.53% and 9.24%, 34.08% and 14.97%, and 59.77% and 31.03%, respectively. Our findings indicated that CKD might cause coronary stenosis to progress, and that eGFR combined with CTCA findings will comprise a useful screening modality for coronary stenosis. (author)