Published 1993 | Version v1
Journal article Metadata-only

In vitro anti-proliferative effect of interferon alpha in solid tumors: A potential predicative test

Creators

  • 1. Institute of Virology, Slovak Academy of Sciences, 84246 Bratislava (Slovak Republic)
  • 2. Derer Hospital, Bratislava (Slovak Republic)
  • 3. National Cancer Institute, Bratislava (Slovak Republic)
  • 4. Cancer Research Institute, Slovak Academy of Sciences, Bratislava (Slovak Republic)

Description

An in vitro test for the anti-proliferative effect of human leukocyte interferon (IFN-alpha) was performed in primary cultures of tumor cells obtained from 32 patients with either malignant melanoma (13), renal carcinoma (4) or bladder carcinoma (15). Our results demonstrated activity of IFN in all three groups of solid tumors. However, appreciable differences in sensitivity to anti-proliferative effect of IFN between individual tumors of the same type were found. The potential of this anti-proliferative test for prediction of treatment response in IFN-therapy is discussed. (author)

Additional details

Publishing Information

Journal Title
Neoplasma
Journal Volume
40
Journal Issue
5
Journal Page Range
p. 293-296
ISSN
0028-2685

INIS

Country of Publication
Slovakia
Country of Input or Organization
Slovakia
INIS RN
29060756
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
AUTORADIOGRAPHY; CELL PROLIFERATION; EXPERIMENTAL DATA; HELA CELLS; IN VITRO; LABELLED COMPOUNDS; LABELLING; LEUKEMIA; MELANOMAS; NUCLEAR MEDICINE; RADIOIMMUNOASSAY; RADIONUCLIDE KINETICS; THYMIDINE; TRACER TECHNIQUES; TRITIUM; TUMOR CELLS; UPTAKE
Descriptors DEC
ANIMAL CELLS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARCINOMAS; DATA; DISEASES; EPITHELIOMAS; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; IMMUNE SYSTEM DISEASES; IMMUNOASSAY; INFORMATION; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; LIGHT NUCLEI; MEDICINE; NEOPLASMS; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIOASSAY; RADIOISOTOPES; RIBOSIDES; TRACER TECHNIQUES; TUMOR CELLS; YEARS LIVING RADIOISOTOPES

Optional Information

Contract/Grant/Project number
Grant GA-SAV-225/1991
Notes
3 tabs., 13 refs.