Published 1978 | Version v1
Journal article Metadata-only

DNA repair deficiency in lymphocytes from patients with actinic keratosis

Creators

  • 1. Glasgow Univ. (UK)

Description

DNA repair activity was measured in peripheral blood lymphocytes from 18 patients with Actinic Keratosis and 18 age-matched control subjects, by comparing the incorporation of 3H-thymidine into cells after irradiation with ultraviolet light with that into unirradiated cells. The incorporation was followed autoradiographically or by measuring acid insoluble radioactivity in cells labelled in the presence of hydroxyurea. The repair activity in lymphocytes from Actinic keratosis patients was only 47.1% (+-6.5%) of that in cells from the control subjects

Additional details

Publishing Information

Journal Title
Bull. Cancer
Journal Volume
65
Journal Issue
3
Series
Bull. Cancer.
Journal Page Range
357-362
ISSN
0007-4551

Conference

Title
Symposium on skin carcinogenesis.
Dates
13 - 14 Jan 1978.
Place
Paris, France.

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
10494309
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference, Numerical Data
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; DNA; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; GRAPHS; LYMPHOCYTES; SKIN DISEASES; TABLES; ULTRAVIOLET RADIATION
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DATA; DATA FORMS; DISEASES; ELECTROMAGNETIC RADIATION; INFORMATION; LEUKOCYTES; NUCLEIC ACIDS; NUMERICAL DATA; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS