Radiation dosimetry estimation of N-(2-[¹⁸F]fluoropropionyl)- L-glutamate based on the mice distribution data

N-(2-[¹⁸F]fluoropropionyl)-L-glutamate([¹⁸F]FPGLU) was a recently developed potential amino acid tracer for tumor imaging with positron emission tomography–computer tomography (PET–CT). The absorbed and effective radiation doses resulting from the intravenous administration of [¹⁸F]FPGLU were estimated using biodistribution data from normal mice. The methodology recommended by Medical Internal Radiation Dose Committee (MIRD) was used to estimate the doses. The highest uptake of [¹⁸F]FPGLU was found in the kidneys, followed by the liver and lung. The kidneys were the organ received the highest absorbed dose, 58.4 μGy/MBq, the brain received the lowest dose, 5.5 μGy/MBq, and other organs received doses in the range of 8.3–11.9 μGy/MBq. The effective dose was 17.0 μSv/MBq. The data show that a 370 MBq (10 mCi) injection of [¹⁸F]FPGLU would lead to an estimated effective dose of 6.3 mSv, which is within the accepted range of routine nuclear medicine investigations. - Highlights: • The absorbed and effective radiation dosimetry of [¹⁸F]FPGLU was estimated using the biodistribution data from normal mice. • A 370 MBq (10 mCi) injection of [¹⁸F] FPGLU would lead to an estimated effective dose of 6.3 mSv, which is within the accepted range of routine nuclear medicine investigations. • [¹⁸F]FPGLU is a safe amino acid PET tracer for imaging and can be used in further clinical study