Cobolt and bleomycin against carcinomas of head and neck. A controlled clinical study

In our controlled study, combined preoperative treatment with cobalt and Bleomycin produced better results than same dosis of cobalt alone. However, no conclusions can be drawn concerning the synergistic effect of the combined treatment or superiority to an increased irradiation dose of cobalt only. We consider that Bleomycin's greatest potential in the treatment of head and neck carcinomas lies in its preoperative use in combination with radiotherapy. Radical surgery is essential to achieve optimal tumour control. (author)