Published June 1993 | Version v1
Journal article Metadata-only

Malignant transformation of syrian golden hamster embryo cells induced by tritiated water and tritiated thymidine in vitro

Creators

  • 1. Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing (China)

Description

Malignant transformation of Syrian golden hamster embryo (SHE) cells was induced in vitro by tritiated water (HTO) and tritiated thymidine (3H-TdR). The results suggest that HTO and 3H-TdR can directly induce malignant transformation of SHE cells in vitro. Concanavalin A agglutination assay was positive. The transformed cells gained the ability to form colonies in soft-agar medium. The results show that malignant transformation of SHE cells was induced by HTO and 3H-TdR but not by 3H-uridine in vitro. It is suggested that malignant transformation of SHE cells was possibly through nuclear DNA damage of target cells, not through the damage of large molecules in cytoplasm

Additional details

Publishing Information

Journal Title
Chinese Journal of Radiological Medicine and Protection
Journal Volume
13
Journal Issue
3
Journal Page Range
p. 163-165.
ISSN
0254-5098
CODEN
ZFYZDY

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
25036317
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CFU; DNA; EMBRYONIC CELLS; ESTRADIOL; HAMSTERS; HEAVY WATER; IN VITRO; MUTAGENESIS; ONCOGENIC TRANSFORMATIONS; RADIATION INJURIES; THYMIDINE; TRITIUM; TRITIUM OXIDES
Descriptors DEC
ANIMAL CELLS; ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; DISEASES; ESTRANES; ESTROGENS; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROGEN COMPOUNDS; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; INJURIES; ISOTOPES; LIGHT NUCLEI; MAMMALS; NUCLEI; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXYGEN COMPOUNDS; PYRIMIDINES; RADIATION EFFECTS; RADIOISOTOPES; RIBOSIDES; RODENTS; STEROID HORMONES; STEROIDS; TRITIUM COMPOUNDS; VERTEBRATES; WATER; YEARS LIVING RADIOISOTOPES