Radioiodinated aliphatic amines as potential pulmonary imaging agents: Pt. 3

The aliphatic amines, 2-methyl- and 2-isopropyl- substituted 6-hydroxy-1-hexylamines were synthesized from ethyl-6-hydroxyhexanoate in 22% and 11% overall chemical yield respectively. 6-hydroxy-1-hexylamine was available commercially. 6-hydroxy-1-hexylamine and its 2-methyl- and 2-isopropyl- substituents were successfully radioiodinated with trimethylsilyl polyphosphate and [131I]-NaI/NaI to afford the corresponding 6-[131I]-labelled amines in 67%, 61% and 55% radiochemical yield respectively and greater than 98% radiochemical purity (specific activity 340 GBq mmol-1). (author)