Published May 1986 | Version v1
Journal article Metadata-only

Incorporation of a new radioactive compound, 4+Sn-117m DTPA, into normal and burred rat femurs

Creators

  • 1. SUNY, Stony Brook

Description

The physical characteristics of a new tin radiopharmaceutical, 4+Sn-117m diethylenetriamine-pentaacetic acid (DTPA), may make this compound appropriate for orthopedic therapeutic application. The physical and biologic half-lives of this tracer are 14 and 7.8 days, respectively. The decay scheme consists of short-range tissue destroying beta, conversion, and Auger electrons, and a 159-keV gamma ray. Significantly, this compound has a high degree of affinity for newly calcified bone at the site of experimental burr holes in contrast to the adjacent bone marrow. Radioactive skeletal retention was one-half of whole body retention

Additional details

Publishing Information

Journal Title
Clin. Orthop. Relat. Res.
Journal Issue
no.206
Series
Clin. Orthop. Relat. Res.
ISSN
0009-921X
CODEN
CORTB

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
18013314
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
AUTORADIOGRAPHY; DTPA; FEMUR; HALF-LIFE; LABELLED COMPOUNDS; RATS; TIN 117; TRACER TECHNIQUES; UPTAKE
Descriptors DEC
AMINO ACIDS; ANIMALS; BODY; CARBOXYLIC ACIDS; CHELATING AGENTS; DAYS LIVING RADIOISOTOPES; DRUGS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; SKELETON; STABLE ISOTOPES; TIN ISOTOPES; VERTEBRATES