Published November 2011 | Version v1
Report Metadata-only

Significance of poly(ADP-ribosylation) enzymes and their inhibitors on heavy ion therapy

Creators

  • 1. National Cancer Center Research Inst., Div. of Genome Stability Research, Tokyo (Japan)
  • 2. Juntendo Univ., Graduate School of Medicine, Tokyo (Japan)
  • 3. National Inst. of Radiological Sciences, Chiba, Chiba (Japan)

Description

Deficiency of poly(ADP-ribose) polymerase-1 (Parp-1) and poly(ADP-ribose) glycohydrolase (Parg) in embryonic stem (ES) cells both show sensitizing effect on g-irradiation. The impact of PARP inhibitor and functional inhibition of Parp-1 and Parg on sensitivity to carbon-ion irradiation was studied. PARP inhibitor caused sensitization effect on carbon-irradiation in MIAPaCa2 pancreatic cancer cells. Parg and Parp-1 deficient ES cells also showed enhanced sensitivity to carbon-ion irradiation. These results suggest that PARP inhibitor and Parg functional inhibition will be useful for the sensitization to heavy ion irradiation. (author)

Part of:
2010 annual report of the research project with heavy ions at NIRS-HIMAC

Additional details

Identifiers

URL
http://id.nii.ac.jp/1657/00073745/;

Publishing Information

Imprint Title
2009 annual report of the research project with heavy ions at NIRS-HIMAC
Imprint Pagination
322 p.
Journal Page Range
p. 90-91
Report number
NIRS-M--244

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
53067161
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Non-conventional Literature
Descriptors DEI
CARBON IONS; CELL KILLING; COLONY FORMATION; DNA REPAIR; ELECTROPHORESIS; GAMMA RADIATION; GENETIC CONTROL; GENETIC RADIATION EFFECTS; HEAVY IONS; HIMAC ACCELERATOR; MICE; RADIOSENSITIVITY; STRAND BREAKS; TUMOR CELLS
Descriptors DEC
ACCELERATORS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; CHARGED PARTICLES; CONTROL; CYCLIC ACCELERATORS; DNA DAMAGES; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; HEAVY ION ACCELERATORS; IONIZING RADIATIONS; IONS; MAMMALS; PEST CONTROL; RADIATION EFFECTS; RADIATIONS; REPAIR; RODENTS; SENSITIVITY; SYNCHROTRONS; VERTEBRATES

Optional Information

Notes
This record replaces 45052094
Secondary number(s)
HIMAC--136