Published September 20, 1994
| Version v1
Journal article
Preparation and characterization of a tritiated derivative of CP-96.345-a nonpeptide antagonist of the substance P receptor-with a high specific radioactivity
- 1. Institute of Biorganic Chemistry, Moscow (Russian Federation)
- 2. Institute of Molecular Genetics, Moscow (Russian Federation)
Description
A tritiated derivative of CP-96.345 with a specific activity of 84 Ci/mmole has been obtained. The radioactive compound has been characterized in comparison with the unlabeled analogue for its capacity for inhibiting the binding of the [125I]iodinated derivative of substance P with brain membrane preparations from various sources. The capacity of [3H]CP-96.345 for directly and specifically binding with membranes from the same sources has also been investigated by the method of radioligand analysis
Additional details
Publishing Information
- Journal Title
- Russian Journal of Bioorganic Chemistry
- Journal Volume
- 20
- Journal Issue
- 11
- Journal Page Range
- p. 657-662.
- ISSN
- 1068-1620
- CODEN
- RJBCET
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 27004304
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Translation
- Descriptors DEI
- BLOOD PRESSURE; CHEMICAL PREPARATION; INFLAMMATION; NEUROREGULATORS; RADIOPHARMACEUTICALS; TRITIUM COMPOUNDS
- Descriptors DEC
- AUTONOMIC NERVOUS SYSTEM AGENTS; DISEASES; DRUGS; HYDROGEN COMPOUNDS; LABELLED COMPOUNDS; MATERIALS; PATHOLOGICAL CHANGES; RADIOACTIVE MATERIALS; SYNTHESIS
Optional Information
- Notes
- Translated from Bioorganicheskaya Khimiya; 20: No. 11, 1162-1168(Nov 1994).