Clinical application of 99Tc-MDP in the treatment of osteonecrosis of femoral head

To explore the mechanism and therapeutic effect of 99Tc-MDP on the treatment of osteonecrosis of femoral head. The eighty-three patients with osteonecrosis of femoral head confirmed by X-ray examination were treated by 99Tc-MDP. The scores of pain,viability activity of joints and walking distance and the clinical effects were observed and analyzed. All patients were followed up in an average period of 12 months. The results showed that the scores of pain and viability of each period after therapy were significantly greater than that before therapy (P < 0.05). The scores of activity of joints and walking distance of the second and the third period after therapy were significantly greater than that before therapy (P < 0.05). The X-ray film results indicated that 81.8% patients followed up more than 18 months showed reparation change of the femoral head. The treatment of osteonecrosis of femoral head by 99Tc-MDP could improve the blood supply of the femoral head, and achieve satisfactory effects. (authors)