Published May 2003 | Version v1
Journal article Metadata-only

A time-resolved study on the photodynamic primary process of ADE. Pt.2: Photochemistry in biomolecular complexes

Creators

  • 1. Chinese Academy of Sciences, Shanghai (China). Shanghai Inst. of Nulcear Research, Laboratory of Radiation Chemistry
  • 2. Chinese Academy of Sciences, Shanghai (China). Shanghai Inst. of Materia Medica

Description

By use of laser flash photolysis and steady state absorption techniques, a systematic study was carried out on the interaction of ADE, which is a kind of model compound of actinomycin D, with DNA and BSA. Non-covalent binding was found between ADE and ssDNA, dsDNA and BSA, and photoinduced electron transfer reaction was observed. These results indicate that actinomycins might be used as type I photodrugs in the future and will be helpful for structure modification of this kind of compound

Additional details

Publishing Information

Journal Title
Journal of Radiation Research and Radiation Processing
Journal Volume
21
Journal Issue
2
Journal Page Range
p. 99-101
ISSN
1000-3436

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
35022638
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ABSORPTION SPECTROSCOPY; ACTINOMYCIN; BIOPHOTOLYSIS; CHEMICAL PROPERTIES; COMPLEXES; DNA; DRUGS; ELECTRON TRANSFER; EVALUATION; HEMOCYANIN; LASER RADIATION; MOLECULAR BIOLOGY; PHOTOCHEMISTRY; PHOTOSENSITIVITY; TIME DEPENDENCE; TRANSIENTS
Descriptors DEC
ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BIOCONVERSION; CHEMICAL REACTIONS; CHEMISTRY; DECOMPOSITION; DRUGS; ELECTROMAGNETIC RADIATION; METALLOPROTEINS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PHOTOCHEMICAL REACTIONS; PHOTOLYSIS; PROTEINS; RADIATIONS; SENSITIVITY; SPECTROSCOPY