Published March 1988
| Version v1
Journal article
Identification of a UV-induced trans-acting protein that stimulates polyomavirus DNA replication
Description
Previous studies provided indirect evidence that the ability of a variety of DNA-damaging agents to induce asynchronous polyomavirus DNA replication in the H3 rat fibroblast cell line is mediated by a trans-acting factor. Using an erythrocyte insertion technique to introduce protein fractions from UV-irradiated cells into unirradiated H3 cells, we have now obtained evidence that this factor is a 60-kilodalton protein. These findings provide evidence that DNA damage in mammalian cells induces a factor that can alter the replication of a viral DNA
Additional details
Publishing Information
- Journal Title
- Journal of Virology
- Journal Volume
- 62
- Journal Issue
- 3
- Series
- J. Virol.
- Journal Page Range
- 1057-1060
- ISSN
- 0022-538X
- CODEN
- JOVIA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 22003117
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIPS; FIBROBLASTS; PHOSPHORUS 32; POLYOMA VIRUS; PROTEINS; RADIATION EFFECTS; RATS; ULTRAVIOLET RADIATION
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; ELECTROMAGNETIC RADIATION; ISOTOPES; LIGHT NUCLEI; MAMMALS; MICROORGANISMS; NUCLEI; NUCLEIC ACID REPLICATION; ODD-ODD NUCLEI; ONCOGENIC VIRUSES; ORGANIC COMPOUNDS; PARASITES; PHOSPHORUS ISOTOPES; RADIATIONS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; VERTEBRATES; VIRUSES