Neuroimaging research progress in Leber hereditary optic neuropathy

Leber hereditary optic neuropathy (LHON) is a hereditary neurological disorder characterized by point mutation in mitochondrial DNA, which cause progressive painless vision loss. Recently, imaging techniques such as optical coherence tomography and magnetic resonance imaging have been used to detect the neuronal damages caused by LHON, which provides potential imaging biomarkers for the prevention and treatment of LHON. This paper systematically reviews the latest neuroimaging progress about the damage of the anterior visual pathway and brain tissues. (authors)