Published July 1979
| Version v1
Journal article
An improved synthesis of 18F-5-fluorouracil
Creators
- 1. University of Southern California, Los Angeles (USA)
Description
18F-F2 produced by the 20Ne(d,α)18F reaction was used to synthesize 25-35 mCi of 18F-5-fluorouracil. The mechanism of reaction of 18F-F2 with uracil in acetic acid was studied by NMR and radiochemical techniques, and the primary reaction intermediate, 18F-5-fluoro-6-acetoxy-5, 6-dihydrouracil, was isolated and identified. A novel fractional sublimation technique used in the synthesis and purification of 18F-5-fluorouracil is described. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Appl. Radiat. Isot.
- Journal Volume
- 30
- Journal Issue
- 7
- Series
- Int. J. Appl. Radiat. Isot.
- Journal Page Range
- 401-405
- ISSN
- 0020-708X
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 10486729
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ALPHA PARTICLES; CHEMICAL PREPARATION; CHEMICAL REACTIONS; DEUTERON REACTIONS; FLUORINE 18; FLUOROURACILS; NEON 20 TARGET; NMR SPECTRA; PURIFICATION; RADIOPHARMACEUTICALS; SUBLIMATION
- Descriptors DEC
- ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHARGED PARTICLES; DRUGS; EVAPORATION; FLUORINE ISOTOPES; HELIUM IONS; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; IONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; NUCLEAR REACTIONS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHASE TRANSFORMATIONS; PYRIMIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SPECTRA; SYNTHESIS; TARGETS; URACILS