Radioimmunoassay of 17 α-hydroxyprogesterone in the saliva
Creators
- 1. Hopital Saint-Louis, Service Biochimie-Hormonologie, 75 - Paris (France)
- 2. Hopital Trousseau, Service Exploration Fonctionnelle, 75 - Paris (France)
Description
The authors describe a method for the radioimmunoassay of 17 α-hydroxyprogesterone in the saliva. The limit of detection is 1.96 fmole/tube. Salivary 17α-hydroxyprogesterone was measured in control subjects. Values found were of 296+-115 pmol/l in the male, and 251+-23 pmol/l in the female during the follicular phase and 401+-94 pmol/l during the luteal phase, and 115+-30 pmol/l in the prepubertal child. Concentrations were much higher in the newborn and decreased during the first days of life. Variations in salivary concentrations were compared with those in plasma 17 α-hydroxyprogesterone during the 24-hour period and with the Synacthene stimulation test. The excellent correlation (r=0.0969) between salivary 17 α-hydroxyprogesterone and plasma 17 α-hydroxyprogesterone in 28 patients being treated for 21 hydroxylase deficiency makes it possible to suggest salivary assay in place of plasma assay in the therapeutic follow-up of such patients
Abstract (French)
Les auteurs decrivent un dosage radioimmunologique de la 17 α-hydroxyprogesterone dans la salive. La methode presente les caracteristiques de specificite et de precision habituellement rencontrees pour ce type de dosages. La limite de detection est de 1,96 fmole/tube. La 17 α-hydroxyprogesterone salivaire a ete dosee chez des sujets temoins. Les valeurs mesurees sont de 296+-23 pmol/l chez l'homme, 251+-23 pmol/l chez la femme pendant la phase folliculaire, 401+-94 pmol/l pendant la phase luteale, 115+-30 pmol/l chez l'enfant impubere. Chez le nouveau-ne, les concentrations sont tres superieures et diminuent pendant les premiers jours de la vie. Les variations des concentrations salivaires ont ete comparees a celles de la 17 α-hydroxyprogesterone plasmatique au cours du nycthemere et de l'epreuve de stimulation par le Synacthene. L'excellente correlation (r=0,969) entre la 17 α-hydroxyprogesterone salivaire et la 17 α-hydroxyprogesterone plasmatique chez 28 patients traites pour une hyperplasie congenitale des surrenales par deficit en 21 hydroxylase permet de proposer le dosage salivaire a la place du dosage plasmatique pour le suivi therapeutique de ces maladesAdditional details
Additional titles
- Original title (French)
- Radioimmunodosage de la 17 α-hydroxyprogesterone salivaire. Valeurs obtenues chez les sujets sains et chez les patient traites pour hyperplasie congenitale des surrenales
Publishing Information
- Journal Title
- Ann. Biol. Clin. (Paris)
- Journal Volume
- 43
- Journal Issue
- 4
- Series
- Ann. Biol. Clin. (Paris).
- Journal Page Range
- 333-337
- ISSN
- 0003-3898
- CODEN
- ABCLA
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 17019282
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ADRENAL GLANDS; BLOOD PLASMA; COMPARATIVE EVALUATIONS; CONGENITAL DISEASES; DIAGNOSIS; PATIENTS; PROGESTERONE; RADIOIMMUNOASSAY; SALIVA
- Descriptors DEC
- BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; DISEASES; ENDOCRINE GLANDS; EVALUATION; GLANDS; HORMONES; ISOTOPE APPLICATIONS; KETONES; MATERIALS; ORGANIC COMPOUNDS; ORGANS; PREGNANES; STEROID HORMONES; STEROIDS; TRACER TECHNIQUES