Clinical application of bone marrow scintigraphy in diagnosing some hematological diseases

The role of the whole-body marrow scintigraphy is studied in evaluating the state of 22 patients (aged 20 to 68 years) with non-Hodgkin lymphoma (NHL), Hodgkin disease (HD), myelomamultiplex, myelofibrosis, polycythaemia vera and anemia aplastica. 99mTc-labeled Nano Albumon (222 Bq) is used. Planar and whole-body scintigraphies are obtained within 30 to 60 min, and 3 to 4 hours post iv injection. Focal and multifocal lesions or diffuse bone marrow infiltration, peripheral extension in the proximal part of long bones, and markedly expressed liver and spleen enlargement are documented. In 17 instances the findings are verified be trephine biopsy. It is concluded that bone marrow scanning is a sensitive and informative method, and in order to make exact diagnosis and staging of patients with systemic disorders the results should be interpreted against the background of clinical and histological findings