Published March 2014 | Version v1
Journal article Metadata-only

Breast cancer patients with metastatic spinal cord compression. Number of extraspinal organs involved by metastases influences survival

Creators

  • 1. University of Luebeck, Department of Medical Oncology and Hematology, Luebeck (Germany)
  • 2. University of Luebeck, University Hospital Schleswig-Holstein, Campus Luebeck, Department of Radiation Oncology, Luebeck (Germany)
  • 3. Hannover Medical University, Department of Radiation Oncology, Hannover (Germany)
  • 4. Mayo Clinic Scottsdale, Department of Radiation Oncology, Arizona (United States)

Description

The goal of the present work was to investigate the predictive value of the number of extraspinal organs involved by metastases for the survival of patients with metastatic spinal cord compression (MSCC) from breast cancer. Data of 145 breast cancer patients who received 10 fractions of 3 Gy of radiotherapy (RT) alone for MSCC were retrospectively analyzed. Seven potential prognostic factors were investigated including age, Eastern Cooperative Oncology Group (ECOG) performance score, number of involved vertebrae, interval from breast cancer diagnosis to RT of MSCC, ambulatory status prior to RT, time to developing motor deficits, and the number of involved extraspinal organs. The 1-year survival rates for involvement of 0, 1, 2, and ≥ 3 extraspinal organs were 86, 73, 36, and 16 % (p < 0.001). In the multivariate analysis, the number of involved extraspinal organs remained significant (risk ratio 2.19; 95 % confidence interval 1.61-3.00; p < 0.001). ECOG performance score (p < 0.001), ambulatory status prior to RT (p = 0.003), and the time to developing motor deficits (p < 0.001) were also significantly associated with survival in the multivariate analysis. The number of extraspinal organs involved by metastases is an independent prognostic factor of survival in patients with MSCC from breast cancer. (orig.)

Availability note (English)

Available from: http://dx.doi.org/10.1007/s00066-013-0473-4

Abstract (German)

In dieser Studie wurde die prognostische Bedeutung der Anzahl metastatisch befallener extraspinaler Organe fuer das Ueberleben von Brustkrebspatientinnen mit metastatisch bedingter Rueckenmarkskompression (MBRK) untersucht. Die Daten von 145 Brustkrebspatientinnen, die eine alleinige Strahlentherapie (RT) mit 10 Fraktionen mit je 3 Gy aufgrund einer MBRK erhielten, wurden retrospektiv ausgewertet. Sieben moegliche Prognosefaktoren wurden untersucht: Alter, Allgemeinzustand (Eastern Cooperative Oncology Group performance score = ECOG-PS), Anzahl befallener Wirbelkoerper, Intervall von der Erstdiagnose der Tumorerkrankung bis zur RT der MBRK, Gehfaehigkeit vor RT, Entwicklungszeit motorischer Defizite und Anzahl metastatisch befallener extraspinaler Organe. Die 1-Jahres-Ueberlebensraten bei Befall von 0, 1, 2 und ≥ 3 extraspinalen Organen betrugen jeweils 86, 73, 36 und 16 % (p < 0,001). In der multivariaten Analyse blieb die Anzahl befallener extraspinaler Organe signifikant (Risk Ratio 2,19; 95 %-Konfidenzintervall 1,61-3,00; p < 0,001). In der multivariaten Analyse waren auch der ECOG-PS (p < 0,001), die Gehfaehigkeit vor RT (p = 0,003) sowie die Entwicklungszeit motorischer Defizite (p < 0,001) signifikant mit dem Ueberleben assoziiert. Die Anzahl metastatisch befallener extraspinaler Organe ist ein unabhaengiger Prognosefaktor fuer das Ueberleben von Brustkrebspatientinnen mit MBRK. (orig.)

Additional details

Identifiers

DOI
10.1007/s00066-013-0473-4;

Publishing Information

Journal Title
Strahlentherapie und Onkologie
Journal Volume
190
Journal Issue
3
Journal Page Range
p. 283-286
ISSN
0179-7158
CODEN
STONE4

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
45066315
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CARCINOMAS; COMPRESSION; CUMULATIVE RADIATION EFFECTS; FRACTIONATED IRRADIATION; GY RANGE 01-10; GY RANGE 10-100; MAMMARY GLANDS; METASTASES; RADIOTHERAPY; SPINAL CORD; SURGERY; SURVIVAL CURVES; SURVIVAL TIME; VERTEBRAE
Descriptors DEC
ABSORBED DOSE RANGE; BODY; CENTRAL NERVOUS SYSTEM; DISEASES; GLANDS; GY RANGE; IRRADIATION; MEDICINE; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIATION DOSE RANGES; RADIATION EFFECTS; RADIOLOGY; SKELETON; THERAPY