THE POSSIBLE EFFECT OF SILDENAFIL CITRATE AND FENUGREEK SEED POWDER ON ENHANCING SERUM TESTOSTERONE LEVELS IN ADULT MALE ALBINO RATS
Creators
- 1. Biological Applications Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, (Egypt)
Description
Sildenafil citrate is a phosphodiesterase 5 inhibitor (PDE5) that increases cyclic guanosine monophosphate (cGMP) which improves vasodilatation and there is a hypothesis that fenugreek seeds have 3 mechanisms by which it may enhance serum testosterone levels. The present study aimed to evaluate the effect of sildenafil citrate and fenugreek seeds alone or in combination on serum testosterone levels in normal adult male albino rats. Besides, total protein, albumin, globulin, bilirubin levels and alanine transaminase, aspartate transaminase and alkaline phosphatase activities were evaluated. The present study claimed that single or combined treatment with sildenafil and fenugreek seed powder (FSP) may enhance serum testosterone levels in adult male albino rats
Additional details
Publishing Information
- Journal Title
- ISOTOPE AND RADIATION RESEARCH
- Journal Issue
- V.40/4
- Journal Page Range
- p. 1071-1080
- ISSN
- 0021-1907
- CODEN
- ISRRAC
INIS
- Country of Publication
- Egypt
- Country of Input or Organization
- Middle Eastern Radioisotope Centre for the Arab Countries (MERRCAC)
- INIS RN
- 40084609
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ALANINES; ALBUMINS; ALKALINE PHOSPHATASE; AMINOTRANSFERASES; BILIRUBIN; BLOOD SERUM; CITRATES; ENZYME INHIBITORS; GLOBULINS; GUANOSINE; HYPOTHESIS; MALES; PHOSPHODIESTERASES; PROTEINS; RATS; SEEDS; TESTOSTERONE; VASODILATION
- Descriptors DEC
- AMINO ACIDS; ANDROGENS; ANDROSTANES; ANIMALS; AROMATICS; AZAARENES; AZOLES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; CARBOXYLIC ACID SALTS; CARBOXYLIC ACIDS; ENZYMES; ESTERASES; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROLASES; HYDROXY COMPOUNDS; KETONES; MAMMALS; MATERIALS; NITROGEN TRANSFERASES; NUCLEOSIDES; NUCLEOTIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHOSPHATASES; PIGMENTS; PROTEINS; PURINES; PYRROLES; RIBOSIDES; RODENTS; STEROID HORMONES; STEROIDS; TRANSFERASES; VERTEBRATES