Prevention of radiation damages with antioxidative nutritional factors and analysis of the modification

We studied the good conditions of diet to storage of carotene and not to decrease vitamin E in organ. When carotene and Na cholate were added to diet, the cumulative dose in rat organ (plasma, liver and bone marrow) increased about ten times, and the vitamin E did not decrease. The best conditions were 50 mg carotene and 50 mg Na cholate per 100 mg diet. Next, using the above diet, the protective effect of carotene in palm oil to the radiation damage was investigated. It was clear that the palm oil carotene with α-carotene and β-carotene protected increase of DNA damage in bone marrow, and decrease of peripheral leukocyte and survival of rat after irradiation, α-carotene was thought to have these activities. (S.Y.)