Published February 1987
| Version v1
Journal article
Treatment of two children with severe hematopolietic radiation syndrome by fetal liver transplantation
Description
Two children with beta-thalassemic were conditioned with cyclophosphamide 40 mg/kg/d x 2 and 6.4-6.6 Gy of 66Co γ-irradiation before fetal liver transplantation (FLT). Then cell suspensions from 4 and 3 fetal livers were prepared. The total nucleated cells infused were 17.7 x 109 and 15.9 x 109 respectively. Both of them successfully recovered from bone marrow aplasia without evidence of severe GVHD. Betathalassemic relapsed 2-3 months after the FLT in both patents. They survived 21 and 19 months after FLT. The results show that FLT is useful in the treatment of acute radiation syndrome in children
Additional details
Publishing Information
- Journal Title
- Chin. J. Radiol. Med. Prot.
- Journal Volume
- 7
- Journal Issue
- 1
- Series
- Chin. J. Radiol. Med. Prot.
- Journal Page Range
- 14-17
- ISSN
- 0254-5098
- CODEN
- ZFYZD
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 19054840
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BONE MARROW; COBALT 60; FETUSES; GAMMA RADIATION; GRAFT-HOST REACTION; INFUSION; LIVER CELLS; RADIATION INJURIES; THERAPY; TRANSPLANTS; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; COBALT ISOTOPES; DISEASES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; INJURIES; INTAKE; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; SOMATIC CELLS; TISSUES; YEARS LIVING RADIOISOTOPES