Published November 1994 | Version v1
Journal article Metadata-only

211At labelling of 3H11 McAb and its effect on DNA and RNA synthesis in gastric cancer cell

Creators

  • 1. Sichuan Univ., Chengdu (China). Inst. of Nuclear Science and Technology

Description

211At-3H11 McAb was prepared with an indirect labelling method which 211At was coupled to 3H11 McAb via paraastato-benzoic acid intermediate. At least 30% of the added 211At was found in the product, the specific activity of which was up to 111 GBq/g McAb. Its radioimmunity was verified by ELISA method. Nuclide precursor incorporation techniques revealed that 211At-McAb inhibited the incorporation of 3H-TdR and 3H-UR into gastric cancer, especially the latter. The inhibition effect was dependent on the concentration of 211At-McAb and was stronger than that of Na211At

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
17
Journal Issue
11
Journal Page Range
p. 697-701.
ISSN
0253-3219
CODEN
NUTEDL

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
26066388
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ASTATINE 211; BIOSYNTHESIS; DNA; LABELLING; MAN; MONOCLONAL ANTIBODIES; NEOPLASMS; RNA; STOMACH; THYMIDINE; TRITIUM; TUMOR CELLS
Descriptors DEC
ALPHA DECAY RADIOISOTOPES; ANIMAL CELLS; ANIMALS; ANTIBODIES; ASTATINE ISOTOPES; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DIGESTIVE SYSTEM; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GASTROINTESTINAL TRACT; HEAVY NUCLEI; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; NUCLEI; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PRIMATES; PYRIMIDINES; RADIOISOTOPES; RIBOSIDES; SYNTHESIS; VERTEBRATES; YEARS LIVING RADIOISOTOPES