Congenital multiple infantile myofibromatosis: Radiological findings

Infantile myofibromatosis (IM) is the most common mesenchymal tumor during childhood. At present, these lesions are classified as solitary myofibromatosis, congenital multiple myofibromatosis associated with multicentric lesions and no organ involvement, and congenital generalized myofibromatosis with skin and visceral involvement. The most frequent presenting sign consists of hard masses located in the skin, subcutaneous tissue, muscle, bone and/or organs. Sixty percent of these lesions are present at birth, and 88% develop during the first two years of life. The disease usually resolves spontaneously. Although the definitive diagnosis is based on the pathological study, knowledge of the radiological features of these lesions is of great value for distinguishing them from malignant mesenchymal tumor. We describe the clinical and pathological features as well as the radiological findings in a newborn with congenital IM who was born with masses in skin, subcutaneous tissue and muscles, but presented no organ involvement. (Author) 15 refs