Published January 1979
| Version v1
Journal article
Thallium-201: quantitation of right ventricular hypertrophy in chronically hypoxic rats
- 1. Children's Hospital Medical Center, Boston, MA
Description
Sprague Dawley rats were divided into two groups. Ten were kept in room air and 10 in hypobaric hypoxia (air at 380 m Hg). After two weeks all were injected intravenously with 50 μCi of 201Tl and sacrificed. The right and left ventricles were separated, weighed, and measured for radioactivity in a gamma well counter. Left and right ventricular mass ratios (MR) correlated with 201Tl radioactivity ratios (TAR) in both control and hypoxic rats: r = 0.962 where MR = 0.863 TAR + 0.27. Myocardial 201Tl uptake reflects and quantitates normal and abnormal ventricular mass, the abnormal mass in this model consisting of right ventricular hypertrophy associated with hypoxic pulmonary hypertension
Additional details
Publishing Information
- Journal Title
- Radiology
- Journal Volume
- 130
- Journal Issue
- 1
- Series
- Radiology.
- Journal Page Range
- 223-225
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 10449071
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANOXIA; BIOLOGICAL EFFECTS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; HYPERTROPHY; MEASURING METHODS; MYOCARDIUM; RATS; THALLIUM 201
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HEART; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPES; RODENTS; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; VERTEBRATES