Published November 7, 2014 | Version v1
Journal article Metadata-only

Epstein-Barr Virus in Gastric Carcinoma

Creators

  • 1. Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1-1-1, Ube, Yamaguchi 755-8505 (Japan)
  • 2. Department of Microbiology, Shimane University Faculty of Medicine, 89-1 Enyacho, Izumo City, Shimane 693-8501 (Japan)
  • 3. Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1-1-1, Ube, Yamaguchi 755-8505 (Japan)
  • 4. Department of Pathology, Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1-1-1, Ube, Yamaguchi 755-8505 (Japan)
  • 5. Department of Clinical Research, National Hospital Organization Kanmon Medical Center, 1-1 Sotoura, Chofu, Shimonoseki, Yamaguchi 752-8510 (Japan)

Description

The Epstein-Barr virus (EBV) is detected in about 10% of gastric carcinoma cases throughout the world. In EBV-associated gastric carcinoma, all tumor cells harbor the clonal EBV genome. Gastric carcinoma associated with EBV has distinct clinicopathological features, occurs predominately in men and in younger-aged individuals, and presents a generally diffuse histological type. Most cases of EBV-associated gastric carcinoma exhibit a histology rich in lymphocyte infiltration. The immunological reactiveness in the host may represent a relatively preferable prognosis in EBV-positive cases. This fact highlights the important role of EBV in the development of EBV-associated gastric carcinoma. We have clearly proved direct infection of human gastric epithelialcells by EBV. The infection was achieved by using a recombinant EBV. Promotion of growth by EBV infection was observed in the cells. Considerable data suggest that EBV may directly contribute to the development of EBV-associated GC. This tumor-promoting effect seems to involve multiple mechanisms, because EBV affects several host proteins and pathways that normally promote apoptosis and regulate cell proliferation

Availability note (English)

Available from http://dx.doi.org/10.3390/cancers6042259; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276965

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276965;
DOI
10.3390/cancers6042259;

Publishing Information

Journal Title
Cancers (Basel)
Journal Volume
6
Journal Issue
4
Journal Page Range
p. 2259-2274
ISSN
2072-6694

INIS

Country of Publication
Switzerland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
47006792
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CARCINOMAS; CELL PROLIFERATION; DNA; METHYLATION; ONCOGENIC VIRUSES; TUMOR CELLS
Descriptors DEC
ANIMAL CELLS; CHEMICAL REACTIONS; DISEASES; MICROORGANISMS; NEOPLASMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PARASITES; VIRUSES

Optional Information

Copyright
Copyright (c) 2014 by the authors
Notes
PMCID: PMC4276965; PMID: 25386788; PUBLISHER-ID: cancers-06-02259; OAI: oai:pubmedcentral.nih.gov:4276965; licensee MDPI, Basel, Switzerland.; This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).