Role of wheat germ oil on some haematological and biochemical indices in rats treated with aluminium chloride

Metals possess numerous benefits, it have distinctive effects on biological system. Currently, investigations focus on natural products' administration within environmental contamination and human health. The present study assesses to investigate the effect of wheat germ oil (WGO) on rats contaminated with aluminium chloride (AlCl3). Female albino rats injected intra peritoneal with 20 mg/kg of Alcl3 for 6 weeks and then 200 mg/kg of WGO for two week in another group and group takes the both treatments.The haematological blood indices and biochemical analysis for iron (Fe), folic acid, B12, Calcium (Ca), phosphorus (P), magnesium (Mg) and acetylcholinesterase (AchE) activity were investigated. Also thymus and spleen were anticipated for histopathological examination. AlCl3 induced significant increased in total leukocytes (WBCs) and lymphocyte counts and significant decreased in erythrocytes (RBCs) count as well as haemoglobin (Hb) and haematocrit (Ht) values. Disturbances in mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) levels as well as platelets counts were also observed in AlCl3 treated animals. Also, AlCl3 induced significant decreased in Fe, folic acid, B12 and Mg concentrations as well as AChE activity. Additionally imbalance between P and Ca was observed. AlCl3 displayed congestion of thymus blood capillaries as well as haemorrhage droplets. In addition, spleen showed marked thickening of splenic capsule associated with inflammatory cells infiltration. WGO administration exhibited an improving in the examined parameters. It could be concluded that supplementation of WGO can protect against free radical damage-induced by AlCl3.