Published October 8, 2013 | Version v1
Journal article Metadata-only

The usefulness of F-18 FDG PET/CT-mammography for preoperative staging of breast cancer: comparison with conventional PET/CT and MR-mammography

Creators

  • 1. Department of Nuclear Medicine, Presbyterian Medical Center, Jeonju, Jeonbuk (Korea, Republic of)
  • 2. Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk (Korea, Republic of)
  • 3. Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk (Korea, Republic of)
  • 4. Department of Nuclear Medicine, Dong-A University Medical Center, Busan (Korea, Republic of)
  • 5. Department of Nuclear Medicine, Eulji University School of Medicine, Daejeon (Korea, Republic of)

Description

The objective of the study was to compare the diagnostic efficacy of an integrated Fluorine-18 fluorodeoxyglucose (F-18 FDG) PET/CT-mammography (mammo-PET/CT) with conventional torso PET/CT (supine-PET/CT) and MR-mammography for initial assessment of breast cancer patients. Forty women (52.0 ± 12.0 years) with breast cancer who underwent supine-PET/CT, mammo-PET/CT, and MR-mammography from April 2009 to August 2009 were enrolled in the study. We compared the size of the tumour, tumour to chest wall distance, tumour to skin distance, volume of axillary fossa, and number of meta-static axillary lymph nodes between supine-PET/CT and mammo-PET/CT. Next, we assessed the difference of focality of primary breast tumour and tumour size in mammo-PET/CT and MR-mammography. Histopathologic findings served as the standard of reference. In the comparison between supine-PET/CT and mammo-PET/CT, significant differences were found in the tumour size (supine-PET/CT: 1.3 ± 0.6 cm, mammo-PET/CT: 1.5 ± 0.6 cm, p < 0.001), tumour to thoracic wall distance (1.8 ± 0.9 cm, 2.2 ± 2.1 cm, p < 0.001), and tumour to skin distance (1.5 ± 0.8 cm, 2.1 ± 1.4 cm, p < 0.001). The volume of axillary fossa was significantly wider in mammo-PET/CT than supine-PET/CT (21.7 ± 8.7 cm3vs. 23.4 ± 10.4 cm3, p = 0.03). Mammo-PET/CT provided more correct definition of the T-stage of the primary tumour than did supine-PET/CT (72.5% vs. 67.5%). No significant difference was found in the number of metastatic axillary lymph nodes. Compared with MR-mammography, mammo-PET/CT provided more correct classification of the focality of lesion than did MR-mammography (95% vs. 90%). In the T-stage, 72.5% of cases with mammo-PET/CT and 70% of cases with MR-mammography showed correspondence with pathologic results. Mammo-PET/CT provided more correct definition of the T-stage and evaluation of axillary fossa may also be delineated more clearly than with supine-PET/CT. The initial assessment of mammo-PET/CT would be more useful than MR-mammography because the mammo-PET/CT indicates similar accuracy with MR-mammography for decision of T-stage of primary breast tumour and more correct than MR-mammography for defining focality of lesion

Availability note (English)

Available from http://dx.doi.org/10.2478/raon-2013-0031; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814285

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814285;
DOI
10.2478/raon-2013-0031;

Publishing Information

Journal Title
Radiology and Oncology
Journal Volume
47
Journal Issue
4
Journal Page Range
p. 390-397
ISSN
1318-2099

INIS

Country of Publication
Slovenia
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
46051408
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACCURACY; BIOMEDICAL RADIOGRAPHY; CHARGES; CHEST; FLUORINE 18; FLUORODEOXYGLUCOSE; LYMPH NODES; MAMMARY GLANDS; METASTASES; NEOPLASMS; NMR IMAGING; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; WOMEN
Descriptors DEC
ANIMALS; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FEMALES; FLUORINE ISOTOPES; GLANDS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; LYMPHATIC SYSTEM; MAMMALS; MAN; MEDICINE; NANOSECONDS LIVING RADIOISOTOPES; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANS; PRIMATES; RADIOISOTOPES; RADIOLOGY; TOMOGRAPHY; VERTEBRATES

Optional Information

Copyright
Copyright (c) by Association of Radiology & Oncology
Notes
PMCID: PMC3814285; PMID: 24294185; PUBLISHER-ID: rado-47-04-390; OAI: oai:pubmedcentral.nih.gov:3814285; This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).