Case report 381: Membranous lipodystrophy (MLD)

A fascinating case of an entity called 'membranous lipodystrophy' has been described in a 35-year-old woman. Multiple, cyst-like disseminated, skeletal lesions were present throughout (except for the spine, innominate bones, ribs and skull). In addition, resorption of bone and a very thin periosteum were identified. Coarse and irregular trabeculae also were noted. Associated with the skeletal lesions in this instance, were hydrocephalus, cerebral cortical atrophy and multiple calcifications in the basal ganglia bilaterally. The development of mental changes and lesions of the central nervous system as indicated are said to be associated consistently with MLD. The cause of the disorder is considered to be unknown. The pathological studies were described in depth and the differential diagnosis was considered. (orig./SHA)