Published May 2021 | Version v1
Journal article Metadata-only

[68Ga]Ga-iPSMA-Lys3-Bombesin: Biokinetics, dosimetry and first patient PET/CT imaging

Creators

  • 1. Unidad PET/CT, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510 (Mexico)
  • 2. Departamento de Posgrado, UPIBI-Instituto Politécnico Nacional, Mexico City 07340 (Mexico)
  • 3. Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico State (Mexico)
  • 4. Unidad de Radiofarmacia-Ciclotrón, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510 (Mexico)

Description

The prostate-specific membrane antigen (PSMA) and the gastrin-releasing peptide receptor (GRPR) are overexpressed in prostate cancer (PCa). In preclinical studies, the iPSMA-Lys3-Bombesin (iPSMA-BN) heterodimeric ligand has shown a suitable affinity for PSMA and GRPR. This research aimed to assess the biokinetics and radiation dosimetry of [68Ga]Ga-iPSMA-BN in four healthy volunteers based on biodistribution data obtained from whole-body PET/CT studies, as well as to visualize the [68Ga]Ga-iPSMA-BN tumor uptake in a patient with PCa.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nucmedbio.2021.03.005

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2021.03.005;
PII
S0969805121000482;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
96
Journal Page Range
p. 54-60
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53120612
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
AFFINITY; ANTIGENS; DOSIMETRY; GALLIUM 68; GASTRIN; LIGANDS; MEMBRANES; NEOPLASMS; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; PROSTATE; RECEPTORS; UPTAKE
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; GALLIUM ISOTOPES; GLANDS; HORMONES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MALE GENITALS; MEMBRANE PROTEINS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIOISOTOPES; TOMOGRAPHY

Optional Information

Copyright
Copyright (c) 2021 Elsevier Inc. All rights reserved.