Published 1986
| Version v1
Journal article
An 131I iodotamoxifen: no carrier added iodination via a diazonium salt
Creators
- 1. University of Western Ontario, London (Canada). Dept. of Chemistry
- 2. University of Western Ontario, London (Canada). Dept. of Nuclear Medicine
Description
An 131I-labeled iodotamoxifen has been prepared by a ''no carrier added'' procedure in a 40% radiochemical yield via an aryl diazonium ion salt intermediate. Two approaches were used to produce high specific activity iodotamoxifen: nonaqueous solvents and copper catalysis. The use of the nonaqueous solvent acetonitrile has proved successful while neither copper powder, copper-bronze, copper(I)oxide nor Cu(II) sulphate showed any catalytic effects. (author)
Additional details
Publishing Information
- Journal Title
- Appl. Radiat. Isot.
- Journal Volume
- 37
- Journal Issue
- 8
- Series
- Appl. Radiat. Isot.
- Journal Page Range
- 889-891
- CODEN
- ARISE
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 18001340
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ACETONITRILE; CARRIER-FREE ISOTOPES; CATALYSIS; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; COPPER; DIAZO COMPOUNDS; IODINE 131; RADIOPHARMACEUTICALS; TAMOXIFEN
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DRUGS; ELEMENTS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; METALS; NITRILES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TRANSITION ELEMENTS