Published 1993 | Version v1
Journal article Metadata-only

Modulation of the clastogenic activity of ionizing radiation and bleomycin by the aminothiol WR-1065

Creators

  • 1. Oak Ridge Institute for Science and Education, TN (United States)
  • 2. College of the Holy Cross, Worcester, MA (United States)

Description

WR-1065 (2-[(aminopropyl)amino]ethanethiol) reduces the induction by ionizing radiation of genetic damage, including DNA single- and double-strand breaks, chromosomal aberrations, micronuclei, and hprt mutations in mammalian cells. The effectiveness of WR-1065 as a radioprotector is apparently enhanced by its tendency, a a cationic thiol, to concentrate near DNA. The authors have studied the modulation by WR-1065 of the induction of chromosome aberrations and micronuclei in G0 human lymphocytes by ionizing radiation and by the radiomimetic chemical bleomycin

Additional details

Publishing Information

Journal Title
Environmental and Molecular Mutagenesis
Journal Volume
22
Journal Issue
4
Journal Page Range
p. 225-230.
ISSN
0893-6692
CODEN
EMMUEG

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
26005487
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
AMINES; BIOLOGICAL RADIATION EFFECTS; DNA REPAIR; NEUTRONS; RADIOPROTECTIVE SUBSTANCES; RADIOSENSITIVITY; STRAND BREAKS; THIOLS; X RADIATION
Descriptors DEC
BARYONS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; FERMIONS; HADRONS; IONIZING RADIATIONS; NUCLEONS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RESPONSE MODIFYING FACTORS