Published April 15, 2019 | Version v1
Journal article Metadata-only

Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells

Creators

  • 1. Ministry of Health of the Russian Federation, Russian Scientific Center of Roentgenoradiology (Russian Federation)

Description

We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation with ultra-high dose rate induced significantly higher levels of "early" apoptosis and lower levels of necrosis compared to γ-radiation with dose rate used for radiation therapy.

Additional details

Identifiers

DOI
10.1007/s10517-019-04440-0;

Publishing Information

Journal Title
Bulletin of Experimental Biology and Medicine
Journal Volume
166
Journal Issue
6
Journal Page Range
p. 785-787
ISSN
0007-4888
CODEN
BEXBAN

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
51091756
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
APOPTOSIS; BIOLOGICAL EFFECTS; CELL CULTURES; DOSE RATES; LYMPHOCYTES; LYMPHOMAS; NECROSIS; RADIOTHERAPY
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; IMMUNE SYSTEM DISEASES; LEUKOCYTES; MATERIALS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; PATHOLOGICAL CHANGES; RADIOLOGY; SOMATIC CELLS; THERAPY

Optional Information

Copyright
Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature