Role of Calcium Pantothenate in Recovery of Radiation Induced Injury to Mammalian Organs
Creators
- 1. Radiation Biology, and Radiation Health Research Departments National Centre for Radiation Research and Technology, Cairo (Egypt)
Description
The aim of the present study was to evaluate the modulator role of calcium pantotthenate on the radiation-induced changes in certain biochemical and histological disorders. Rats were exposed to a total dose of 6Gy of gamma-radiation, delivered as three doses of 2 Gy at 3 days intervals. During two days before each irradiation dose, animals received a daily intraperitoneal administration of 20 mg calcium pantothenate/kg b wt. Animals were sacrificed on the 1st h, 1st week and 2nd week after the third irradiation session. Blood and livers were removed for biochemical analysis. Histological examination was performed on liver tissues. The results obtained revealed that treatment with calcium pantothenate diminished the amount of thiobarbituric acid-reactive substances (TBARS) in comparison with the levels recorded in the plasma and liver of irradiated rats. Significant amelioration of the radiation-induced changes in the contents of reduced (GSH), total cholestererol, total phospholipids and total free fatty acids were also recorded in the plasma and liver of calcium pantothenate-treated and irradiated rats
Additional details
Publishing Information
- Journal Title
- Egyptian Journal of Radiation Sciences and Applications
- Journal Volume
- 18
- Journal Issue
- 1
- Journal Page Range
- p. 17-38
- ISSN
- 1110-0303
INIS
- Country of Publication
- Egypt
- Country of Input or Organization
- Egypt
- INIS RN
- 36037006
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BLOOD; BLOOD VESSELS; CALCIUM; CARBOXYLIC ACIDS; CHOLESTEROL; FIBROBLASTS; LIPIDS; LIVER; MALES; MAMMALS; MAMMARY GLANDS; PHOSPHOLIPIDS; PHOTOMICROGRAPHY; RADIATION DOSES; RADIATION INJURIES; RATS; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ALKALINE EARTH METALS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CONNECTIVE TISSUE CELLS; DIGESTIVE SYSTEM; DISEASES; DOSES; ELEMENTS; ESTERS; EXTERNAL IRRADIATION; GLANDS; HYDROXY COMPOUNDS; INJURIES; IRRADIATION; LIPIDS; MAMMALS; MATERIALS; METALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANS; PHOTOGRAPHY; RADIATION EFFECTS; RODENTS; SOMATIC CELLS; STEROIDS; STEROLS; VERTEBRATES