Published April 1977 | Version v1
Journal article Metadata-only

Tissue distribution of 1,2-14C-vinyl chloride in rats

Creators

  • 1. Tuebingen Univ. (Germany, F.R.)
  • 2. Koeln Univ. (Germany, F.R.)

Description

Rats have been pretreatet with 6-nitro-1.2.3-benzothiadiazole which completely blocks the metabolism of vinyl chloride. If the animals are exposed to atmospheric vinyl chloride, the formation of an equilibrium between the compound in the gas phase and in the animal's organism is observed. Unmetabolized vinyl chloride is accumulated in the adipose tissue. The distribution pattern of vinyl in different organs of the rat is constant over the concentration range of 25-10,000 ppm of vinyl chloride in the exposure atmosphere. The distribution of metabolites of vinyl chloride contrasts to that of the original compound; metabolites primarily are concentrated in liver and in kidneys. (orig.)

Abstract (German)

Wird Vinylchlorid aus der Atmosphaere eingeatmet, so stellt sich ein Gleichgewicht zwischen dem Vinylchlorid in der Luft und dem Organismus ein. In erster Linie reichert sich nicht metabolisiertes Vinylchlorid im Fettgewebe an. Fuer dieses Verteilungsverhalten duerfte die Lipophilie des Vinylchlorid Ausschlag gebend sein. Das Konzentrationsverhaeltnis von Vinylchlorid in einzelnen Organen bleibt ueber den gesamten untersuchten Konzentrationsbereich von 25 bis 10.000 ppm Vinylchlorid in der Expositionsatmosphaere konstant. Aus dem Gleichgewicht wird Vinylchlorid dem Metabolismus zugefuehrt. Metabolite reichern sich, im Gegensatz zum unveraenderten Vinylchlorid, vor allem in Leber und Niere an. (orig.)

Additional details

Additional titles

Original title (German)
Die Gewebsverteilung von 1,2-

Identifiers

DOI
10.1007/bf00381548;

Publishing Information

Journal Title
International Archives of Occupational and Environmental Health
Journal Volume
39
Journal Issue
1
Series
Int. Arch. Occup. Environ. Health.
Journal Page Range
27-32
ISSN
0340-0131

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
8337701
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ADIPOSE TISSUE; CARBON 14 COMPOUNDS; CARCINOGENS; DISTRIBUTION; INHALATION; INHIBITION; KIDNEYS; LIVER; METABOLISM; ORGANIC CHLORINE COMPOUNDS; RATS; TISSUES; TRACER TECHNIQUES; VINYL MONOMERS
Descriptors DEC
ANIMALS; BODY; CARBON COMPOUNDS; CONNECTIVE TISSUE; DIGESTIVE SYSTEM; GLANDS; INTAKE; ISOTOPE APPLICATIONS; MAMMALS; MONOMERS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; RODENTS; VERTEBRATES

Optional Information

Notes
1 fig.; 2 tabs.; with refs.; Updated automatically by Metadata and Full-Text Enrichment Agent