Published 1990
| Version v1
Book
Kinetics and mechanism of mono and diiodination of tyrosine by molecular iodine and chloramine-T/I-
Description
The observed rate constant ratio, K1obs/K2obs, for the mono- to diiodination of tyrosine has been determined by the use of 3H and 14C-tyrosine and product analysis by HPLC. The K1obs/K2obs values at pH 7.50 and 5.00 were in the range 1.31 ± 0.06 to 1.20 ± 0.04 for chloramine-T/I- iodinations and 1.17 ± 0.09 to ± 0.83 ± 0.22 for molecular iodine iodinations. Chloramine-T/I- iodinations in water/ethanol mixtures have shown an increase in K1obs/K2obs with increased ethanol content. This is in contrast to the contention that the preferential diiodination of buried tyrosyls in proteins is due to the decreased polarity of the microenvironment. 13 refs., 3 tabs., 2 figs
Additional details
Publishing Information
- Publisher
- Wollongong University Printery Services.
- Imprint Place
- Wollongong (Australia)
- ISBN
- 0 642 59902 5
- Imprint Title
- Advances in radiopharmacology: proceedings of the six international symposium on radiopharmacology
- Imprint Pagination
- 314 p.
- Journal Page Range
- p. 268-274.
Conference
- Title
- 6. International symposium on radiopharmacology.
- Dates
- 24-26 Aug 1989.
- Place
- Sydney (Australia).
INIS
- Country of Publication
- Australia
- Country of Input or Organization
- Australia
- INIS RN
- 22018587
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Resource subtype / Literary indicator
- Conference, Numerical Data
- Descriptors DEI
- ACTIVITY LEVELS; BIOCHEMICAL REACTION KINETICS; CHEMICAL PREPARATION; CHLORAMINES; EXPERIMENTAL DATA; IODINATION; IODINE 125; IODINE 131; LABELLING; LIQUID SCINTILLATION DETECTORS; OXIDATION; PERMITTIVITY; PROTEINS; RADIOACTIVATION; TRITIUM; TYROSINE
- Descriptors DEC
- AMINES; AMINO ACIDS; AROMATICS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DATA; DAYS LIVING RADIOISOTOPES; DIELECTRIC PROPERTIES; ELECTRICAL PROPERTIES; ELECTRON CAPTURE RADIOISOTOPES; HALOGENATION; HYDROGEN ISOTOPES; HYDROXY ACIDS; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; KINETICS; LIGHT NUCLEI; MEASURING INSTRUMENTS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; PHYSICAL PROPERTIES; RADIATION DETECTORS; RADIOISOTOPES; REACTION KINETICS; SCINTILLATION COUNTERS; SYNTHESIS; YEARS LIVING RADIOISOTOPES