Published December 1982 | Version v1
Report Metadata-only

Toxic effects of inhaled 244Cm2O3 in rats. II

Creators

Description

The toxicity of 244Cm2O3 is being studied in rats exposed by inhalation to monodisperse aerosols to achieve desired initial lung burdens of 2, 6, 17, 45, 150 and 450 nCi of 244Cm. Curium-243 is being used to label the 244Cm2O3 so that the initial lung burden of each rat can be determined. A total of 1000 exposed rats and 158 sham-exposed control rats are being held for life span observation. Fourteen percent of the 1158 rats being held for life span have died through approx. 500 days after exposure. Deaths were due to radiation-induced lung injury or natural causes; no lung tumors were found

Additional details

Publishing Information

Imprint Title
Inhalation Toxicology Research Institute. Annual report, October 1, 1981-September 30, 1982
Journal Page Range
p. 357-360.
Report number
LMF--102

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
15001801
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CURIUM OXIDES; CURIUM 244; INHALATION; LIFE SPAN; LUNGS; RADIATION DOSES; RADIATION EFFECTS; RADIATION INJURIES; RADIOACTIVE AEROSOLS; RATS
Descriptors DEC
ACTINIDE COMPOUNDS; ACTINIDE NUCLEI; AEROSOLS; ALPHA DECAY RADIOISOTOPES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CHALCOGENIDES; COLLOIDS; CURIUM COMPOUNDS; CURIUM ISOTOPES; DISEASES; DISPERSIONS; EVEN-EVEN NUCLEI; HEAVY NUCLEI; INJURIES; INTAKE; ISOTOPES; MAMMALS; NUCLEI; ORGANS; OXIDES; OXYGEN COMPOUNDS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; SOLS; TRANSPLUTONIUM COMPOUNDS; TRANSURANIUM COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES