Published 1986
| Version v1
Book
Purine metabolism in human neuroblastoma cell lines
- 1. The Hospital for Sick Children, Toronto, Ontario
Description
This paper describes in detail the metabolism of purine nucleotide as a possible target for chemotherapy in neuroblastoma. Two different human neuroblastoma cell lines established from surgically resected tumor were used in the study. For the assessment of nucleotide metabolism, labelled adenine, hypoxanthine, adenosine, guanosine, formic acid and glycine were used, and the incorporation of radioactivity into the respective purine ribonucleotides, ribonucleosides and bases was assayed. The cutotoxic effect of a number of drugs was evaluated in a chonogenic assay
Additional details
Publishing Information
- Publisher
- Plenum Press.
- Imprint Place
- New York, NY (USA)
- Imprint Title
- Purine and pyrimidine metabolism in man V
- Journal Page Range
- p. 357-362.
Conference
- Title
- 5. international symposium on human purine and pyrimidine metabolism.
- Dates
- 28 Jul - 1 Aug 1985.
- Place
- San Diego, CA (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18051136
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BIOLOGICAL PATHWAYS; CHEMICAL ACTIVATION; CHEMOTHERAPY; COMPARATIVE EVALUATIONS; DEAMINATION; DEHYDROGENASES; ENZYME ACTIVITY; LIGASES; METABOLISM; NERVE CELLS; NUCLEOTIDES; PHOSPHORYLATION; PURINES; RADIOENZYMATIC ASSAY; TRANSFERASES; TRITIUM COMPOUNDS; TUMOR CELLS; UPTAKE
- Descriptors DEC
- ANIMAL CELLS; CHEMICAL REACTIONS; ENZYMES; EVALUATION; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; MEDICINE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXIDOREDUCTASES; SOMATIC CELLS; THERAPY