Published September 2015 | Version v1
Journal article Metadata-only

Therapeutic combination of radiolabeled CLR1404 with external beam radiation in head and neck cancer model systems

Creators

  • 1. Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison (United States)
  • 2. Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison (United States)
  • 3. Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison (United States)

Description

Background and purpose: CLR1404 is a phospholipid ether that exhibits selective uptake and retention in malignant tissues. Radiolabeled CLR1404 enables tumor-specific positron-emission tomography (PET) imaging (124I) and targeted delivery of ionizing radiation (131I). Here we describe the first preclinical studies of this diapeutic molecule in head and neck cancer (HNC) models.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2015.06.015

Additional details

Identifiers

DOI
10.1016/j.radonc.2015.06.015;
PII
S0167814015002972;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
116
Journal Issue
3
Journal Page Range
p. 504-509
ISSN
0167-8140
CODEN
RAONDT

INIS

Country of Publication
Ireland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
50080899
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ETHERS; HEAD; IODINE 124; IODINE 131; IONIZING RADIATIONS; NECK; NEOPLASMS; PHOSPHOLIPIDS; POSITRON COMPUTED TOMOGRAPHY; UPTAKE
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; ESTERS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LIPIDS; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; RADIATIONS; RADIOISOTOPES; TOMOGRAPHY

Optional Information

Copyright
Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.