Published December 16, 2014 | Version v1
Journal article Metadata-only

Muonium response to oxygen content in biological aqueous solutions for cancer research

Creators

  • 1. Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 4-3-11 Takeda, Kofu, 400-8511 (Japan)
  • 2. Atomic Physics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
  • 3. Muon Science Laboratory, IMSS. KEK, Oho, Tsukuba, Ibaraki (Japan)
  • 4. ISIS, Rutherford Appleton Laboratory, Oxford (United Kingdom)
  • 5. Catalysis Research Centre, Hokkaido University, Sapporo (Japan)
  • 6. Advanced Meson Science Laboratory, RIKEN, 2-1Hirosawa, Wako (Japan)
  • 7. Department of Bio-engineering, University of California, Riverside (United States)

Description

Muonium (Mu), which is known to exhibit a characteristic concentration dependent spin relaxation change when impacting molecular oxygen dissolved in water, was found to show a similar behaviour in aqueous solutions of Tris Buffered Saline (TBS), albumin, serum, and hemoglobin (Hb). These effects, along with the interaction of Mu with deoxy-Hb (which is modulated by oxygen by the formation of oxy-Hb) suggest that the muon method can be applied to systematic studies of oxygen dependent effects in biological systems. This muon method may particularly be applicable at low (hypoxic) oxygen levels, an important consideration in the radiation treatment of cancer

Availability note (English)

Available from http://dx.doi.org/10.1088/1742-6596/551/1/012043

Additional details

Identifiers

DOI
10.1088/1742-6596/551/1/012043;

Publishing Information

Journal Title
Journal of Physics. Conference Series (Online)
Journal Volume
551
Journal Issue
1
Journal Page Range
[6 p.]
ISSN
1742-6596

Conference

Title
13. International Conference on Muon Spin Rotation, Relaxation and Resonance
Dates
1-6 Jun 2014
Place
Grindelwald (Switzerland)

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
47010314
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ALBUMINS; AQUEOUS SOLUTIONS; BUFFERS; CONCENTRATION RATIO; HEMOGLOBIN; INTERACTIONS; MUON SPIN RELAXATION; MUONIUM; MUONS; NEOPLASMS; OXYGEN; WATER
Descriptors DEC
CARBOXYLIC ACIDS; DIMENSIONLESS NUMBERS; DISEASES; DISPERSIONS; ELEMENTARY PARTICLES; ELEMENTS; FERMIONS; GLOBINS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HOMOGENEOUS MIXTURES; HYDROGEN COMPOUNDS; LEPTONS; MIXTURES; NONMETALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXYGEN COMPOUNDS; PIGMENTS; PORPHYRINS; PROTEINS; RELAXATION; SOLUTIONS