Published October 1978 | Version v1
Journal article Metadata-only

Immunoreactive 'TSH' in urinary concentrates of Graves' disease patients

Creators

  • 1. Hopital de l'Antiquaille, 69 - Lyon (France). Faculte de Medecine
  • 2. California Univ., Los Angeles (USA). Dept. of Medicine

Description

A double antibody radioimmunoassay was used to analyse immunoreactive thyrotrophin in urinary concentrates from fourteen patients with hyperthyroidism due to Graves' disease, in three subjects with primary hypothyroidism, and in six normal subjects. Immunoreactive thyrotrophin was detectable in eleven subjects with Graves' disease, in one subject with primary hypothyroidism, and in four normal subjects. The mean urinary thyrotrophin concentration was significantly higher in Graves' disease (492+-99.9μU/24h(SEM)(n=11)) than in normal subjects (177+-26.4μU/24h(SEM)(n=4)(P<0.01)). (orig.)

Abstract (German)

Ein Doppelantikoerper-RIA wurde zur Analyse von immunreaktivem Thyrotrophin in Harnkonzentraten von 14 Patienten mit Basedowscher Hyperthyreose, 3 Patienten mit primaerer Hypothyreose und 6 Gesunden untersucht. Dabei wurde immunreaktives Thyrotropin bei 11 Basedow-Patienten, einem Patienten mit primaerer Hypothyreose und bei 4 Gesunden festgestellt. Die mittlere Thyrotropinkonzentration im Harn war bei Basedow-Patienten signifikant hoeher als bei Gesunden (492+-99,9μU/24h (SEM)(n=11)) gegenueber (177+-26,4μU/24h (SEM)(n=4)(P<0,01)). (orig.)

Additional details

Additional titles

Subtitle (English)
A radioimmunoassay artefact

Publishing Information

Journal Title
Eur. J. Clin. Invest.
Journal Volume
8
Journal Issue
5
Series
Eur. J. Clin. Invest.
Journal Page Range
295-301

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
10470171
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
HYPOTHYROIDISM; IMMUNOLOGY; IODINE 131; LABELLING; PATIENTS; RADIOIMMUNOASSAY; TSH; URINE
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; DAYS LIVING RADIOISOTOPES; DISEASES; ENDOCRINE DISEASES; HORMONES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; PEPTIDE HORMONES; PITUITARY HORMONES; RADIOISOTOPES; TRACER TECHNIQUES; WASTES