A comparison of 99mTc-MIBI myocardial SPET with electron beam computed tomography in the assessment of coronary artery disease
Creators
- 1. Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union of Medical College, Beijing, 100037 (China)
Description
We compared technetium-99m methoxyisobutylisonitrile (MIBI) myocardial perfusion single-photon emission tomography (SPET) (MPS) and electron beam computed tomography (EBCT) in order to assess their respective value in the detection of coronary artery disease (CAD). 99mTc-MIBI SPET (stress-resting) and EBCT studies were performed in 51 patients with suspected CAD who underwent coronary angiography (CAG). CAG showed that of the 51 patients, 36 had coronary stenosis ≥50% while 15 had normal results. A moderate positive rank correlation was found between coronary calcification detected by EBCT and MPS score (rs=0.5283, P<0.01). The concordance between EBCT and MPS for the evaluation of CAD was 72.5% (37/51). The sensitivity of EBCT in detecting CAD in 51 patients was comparable to that of MPS (81% vs 94%, NS). However, the accuracy of EBCT was lower than that of MPS (78% vs 94%, P<0.025). As regards the detection of individual coronary artery disease, there was no significant difference in sensitivity between EBCT and MPS (65% vs 75%, NS); however, the specificity and accuracy of EBCT were lower than those of MPS (specificity: 77% vs 95%, P<0.005; accuracy 71% vs 85%, P<0.005). The sensitivity, specificity and accuracy of MPS in detecting single-vessel disease were higher than those of EBCT (sensitivity: 86% vs 42%, P<0.025; specificity: 96% vs 70%, P<0.025; accuracy: 93% vs 61%, P<0.005). However, no significant differences in the sensitivity, specificity and accuracy of MPS and EBCT were found in respect of multivessel disease. In conclusion: 99mTc-MIBI myocardial perfusion SPET and EBCT provide different information in the assessment of CAD. The sensitivity of EBCT for the detection of CAD is comparable with that of MPS; however, the specificity and accuracy of EBCT are lower than those of MPS. More reliable results will be obtained if both myocardial perfusion SPET and EBCT are performed. (orig.). With 1 fig., 4 tabs
Additional details
Publishing Information
- Journal Title
- European Journal of Nuclear Medicine
- Journal Volume
- 24
- Journal Issue
- 9
- Journal Page Range
- p. 1115-1120.
- ISSN
- 0340-6997
- CODEN
- EJNMD9
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 28074673
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ACCURACY; BLOOD FLOW; CARDIOVASCULAR DISEASES; COMPARATIVE EVALUATIONS; COMPUTERIZED TOMOGRAPHY; DIAGNOSIS; ELECTRON BEAMS; IMAGES; ISONITRILES; MYOCARDIUM; PATIENTS; RADIOPHARMACEUTICALS; SENSITIVITY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPECIFICITY; TECHNETIUM COMPLEXES; TECHNETIUM 99
- Descriptors DEC
- ANIMALS; BEAMS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBONIC ACID DERIVATIVES; CARDIOVASCULAR SYSTEM; COMPLEXES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; HEART; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LEPTON BEAMS; MAMMALS; MAN; MATERIALS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PARTICLE BEAMS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPES; TECHNETIUM ISOTOPES; TOMOGRAPHY; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; YEARS LIVING RADIOISOTOPES