Published 1978 | Version v1
Miscellaneous Restricted

The influence of fractionated irradiation on the incorporation rate of a radioactive DNA-precursor

Creators

  • 1. Kernforschungsanlage Juelich G.m.b.H. (Germany, F.R.). Inst. fuer Medizin

Description

An increase of 125I-UdR incorporation with increasing fractionation interval was observed, in dependence of the doses administered. The effect was larger in whole body experiments than in bone marrow labelling experiments. After γ-irradiation the increase was higher than after neutron irradiation and could be observed even after shorter fractionation intervals. Compared with a single irradiation, the 125I-UdR incorporation after fractionated irradiation with intervals of 4 hours was about 20% higher after γ-irradiation, but only about 7% higher after neutron irradiation. (orig./AJ)

Availability note (English)

MF available from INIS under the Report Number.

Abstract (German)

In Abhaengigkeit von der verabreichten Dosis wurde mit zunehmender Fraktionierung auch eine zunehmende Inkorporation von 125J-UdR beobachtet. Dieser Effekt war bei Ganzkoerperversuchen staerker ausgepraegt als bei Knochenmarkmarkierungsversuchen. Nach γ-Bestrahlung war die Zunahme staerker als nach Neutronenbestrahlung. Im Vergleich zu Einzelbestrahlungen war die 125J-UdR-Inkorporation nach fraktionierter Bestrahlung im Abstand von 4 Stunden bei Gammabestrahlung um 20% hoeher, bei Neutronenbestrahlung dagegen nur um ca. 7%. (orig./AJ)

Files

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Additional details

Additional titles

Subtitle (English)
External measurements with iodine-125-deoxyuridine (125-IUdR)

Publishing Information

Imprint Pagination
10 p.
Report number
INKA-Conf--78-077-028

Conference

Title
14. annual meeting of the European Society of Radiation Biology.
Dates
9 - 13 Oct 1978.
Place
Juelich, Germany, F.R.

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
10461036
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOSYNTHESIS; BONE MARROW CELLS; CELL PROLIFERATION; CYCLOTRON RADIATION; DNA; DNA REPLICATION; FRACTIONATED IRRADIATION; GAMMA RADIATION; GENETIC RADIATION EFFECTS; IN VIVO; LABELLING; MEV RANGE 01-10; MICE; NEUTRONS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BARYONS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BREMSSTRAHLUNG; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; ENERGY RANGE; FERMIONS; GENETIC EFFECTS; HADRONS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MEV RANGE; NUCLEIC ACID REPLICATION; NUCLEIC ACIDS; NUCLEONS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; SYNTHESIS; VERTEBRATES