Physiological and radio-induced modulations of low-weight globulins in distinct vascular compartments

The main goal was to investigate the profiles of molecular weight globulins lower than albumin in the electrophoresis system in function of the exposition time to gamma radiation. At 72 h post-irradiation, the globulin electrophoretic profiles bellow albumin showed significant radio-induced changes. In addition, the vascular system, specifically the inferior vena cava, kidney, spleen, jugular, hepatic, and pulmonary veins presented a physiological compartmental distribution of globulins. The findings pointed out the radio-induced alterations of the serum globulin concentrations as a late event, possibly related to a radio modulation of the genes' expression. (author)