T cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants
Creators
- 1. DEpartment of Immunology, University of Alberta, Edmonton, Canada
Description
Culture conditions have been established that allow the induction of delayed-type hypersensitivity (DTH) precursor cells present in a cell population derived from unsensitized spleen cells only when antigen-specific, radioresistant, Thy-1-bearing helper cells are added. This specific cellular cooperation acts via the linked recognition of two determinants on the antigen; thus, cells primed to the protein antigen fowl gamma globulin (FGG) will only allow the induction of DTH reactivity against the second antigen, burro erythrocyte (BRBC), when the conjugate FGG-BRBC is present in the cultures. The requirement for physical linkage between the two antigens has been demonstrated by the observation that DTH to BRBC is induced when the conjugate FGG-BRBC is present and not when BRBC and FGG are given an uncoupled molecules
Additional details
Publishing Information
- Journal Title
- J. Exp. Med.
- Journal Volume
- 155
- Journal Issue
- 4
- Series
- J. Exp. Med.
- Journal Page Range
- 1037-1049
- ISSN
- 0022-1007
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 13707780
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANIMAL CELLS; ANTIGENS; LYMPHOCYTES; RADIOSENSITIVITY; SPLEEN
- Descriptors DEC
- BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; LEUKOCYTES; ORGANS; SOMATIC CELLS