Published 2008 | Version v1
Journal article Metadata-only

211At-Rh(16-S4-diol) - initial complex of radiopharmaceuticals labelled with astatine

Creators

  • 1. Ob''edinennyj Inst. Yadernykh Issledovanij, Laboratoriya Yadernykh Problem, Dubna (Joint Institute for Nuclear Research (JINR))
  • 2. Otdel Radiokhimii Instituta Yadernoj Khimii i Tekhnologii, Varshava (Poland)

Description

Paper describes a new procedure to synthesize a pharmaceutical containing 211At. 211At- anion was found to bind strongly with Rh3+ cation complexing with a thio-ether ligand - 1,5,9,13-tetratiacyclohexadecane-3,11-diol (16-S4-diol). One made use of 131I isotope to seek for the optimal conditions of the reaction. The derived complexes were studied by means of the paper electrophoresis, the ion exchange, the surface chromatography. One studied the kinetics of 131I- anion binding with Rh(16-S4-diol), the dependence of the yield of 131I-Rh(16-S4-diol) forming complex on the temperature. the acidity of the reaction mixture and the concentration of the reagents. On the basis of the determined conditions of the synthesis one prepared 211At-Rh(16-S4-diol) complex by more astatide (211At-) to the equivalent amounts of RhCl3 and tetra-thio-ether (16-S4-diol). One studied its behaviour

Abstract (Russian)

Предлагается новый метод синтеза фармпрепарата, содержащего 211At. Найдено, что анион 211At- образует прочную связь с катионом Rh3+, входящим в комплекс с тиоэфирным лигандом - 1,5,9,13-тетратиациклогексадекан-3,11-диолом (16-S4-diol). Поиски оптимальных условий реакции выполнены с изотопом 131I. Полученные комплексы изучены методами бумажного электрофореза, ионного обмена, тонкослойной хроматографии. Изучены кинетика присоединения аниона 131I- к Rh(16-S4-diol), зависимость выхода образующегося комплекса 131I-Rh(16-S4-diol) от температуры, кислотности реакционной смеси и концентрации реагентов. Исходя из найденных условий синтеза комплекс 211At-Rh(16-S4-dioI) получен при добавлении астатида (211At-) к эквивалентным количествам RhCl3 и тет-ратиоэфира (16-S4-diol). Изучено его поведение

Additional details

Additional titles

Original title (Russian)
Ат-Рх(16-S4-диол) - исходный комплекс радиофармпрепарата, меченного астатом

Publishing Information

Journal Title
Radiokhimiya
Journal Volume
50
Journal Issue
2
Journal Page Range
p. 178-182
ISSN
0033-8311
CODEN
RADKAU

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
39097564
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ASTATINE 211; ASTATINE COMPLEXES; CHEMICAL PREPARATION; CHEMICAL REACTION KINETICS; CHEMICAL REACTION YIELD; CONCENTRATION RATIO; GLYCOLS; IODINE 131; IODINE COMPLEXES; RADIOPHARMACEUTICALS; TEMPERATURE DEPENDENCE
Descriptors DEC
ALCOHOLS; ALPHA DECAY RADIOISOTOPES; ASTATINE ISOTOPES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; COMPLEXES; DAYS LIVING RADIOISOTOPES; DIMENSIONLESS NUMBERS; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; REACTION KINETICS; SYNTHESIS; YIELDS

Optional Information

Notes
13 refs., 6 figs., 1 tab.