Validation of a simplified scatter correction method for 3D brain PET with ¹⁵O

Positron emission tomography (PET) enables quantitative measurements of various biological functions. Accuracy in data acquisition and processing schemes is a prerequisite for this. The correction of scatter is especially important when a 3D PET scanner is used. The aim of this study was to validate the use of a simplified calculation-based scatter correction method for ¹⁵O studies in the brain. We applied two scatter correction methods to the same ¹⁵O PET data acquired from patients with cerebrovascular disease (n = 10): a hybrid dual-energy-window scatter correction (reference method), and a deconvolution scatter correction (simplified method). The PET study included three sequential scans for ¹⁵O-CO, ¹⁵O-O₂, and ¹⁵O-H₂O, from which the following quantitative parameters were calculated, cerebral blood flow, cerebral blood volume, cerebral metabolic rate of oxygen, and oxygen extraction fraction. Both scatter correction methods provided similar reconstruction images with almost identical image noise, although there were slightly greater differences in white-matter regions compared with gray matter regions. These differences were also greater for ¹⁵O-CO than for ¹⁵O-H₂O and ¹⁵O-O₂. Region of interest analysis of the quantitative parameters demonstrated that the differences were less than 10% (except for cerebral blood volume in white-matter regions), and the agreement between the methods was excellent, with intraclass correlation coefficients above 0.95 for all the parameters. The deconvolution scatter correction despite its simplified implementation provided similar results to the hybrid dual-energy-window scatter correction. We consider it suitable for application in a clinical ¹⁵O brain study using a 3D PET scanner. (author)